Article
High Prevalence of a Monogenic Cause in Han Chinese Diagnosed With Type 1 Diabetes, Partly Driven by Nonsyndromic Recessive WFS1 Mutations.
Diabetes - 1 Jan 2020
Li Meihang, Wang Sihua, Xu Kuanfeng, Chen Yang, Fu Qi, Gu Yong, Shi Yun, Zhang Mei, Sun Min, Chen Heng, Han Xiuqun, Li Yangxi, Tang Zhoukai, Cai Lejing, Li Zhiqiang, Shi Yongyong, Yang Tao, Polychronakos Constantin
Abstract excerpt
It is estimated that ∼1% of European ancestry patients clinically diagnosed with type 1 diabetes (T1D) actually have monogenic forms of the disease. Because of the much lower incidence of true T1D in East Asians, we hypothesized that the percentage would be much higher. To test this, we sequenced the exome of 82 Chinese Han patients clinically diagnosed with T1D but negative for three autoantibodies. Analysis...
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