Article
THUMP domain containing 2 protein possibly induces resistance to cisplatin and 5-fluorouracil in in vitro human esophageal squamous cell carcinoma cells as revealed by transposon activation mutagenesis.
The journal of gene medicine - 1 Dec 2019
Hayashi Masato, Kawakubo Hirofumi, Fukuda Kazumasa, Mayanagi Shuhei, Nakamura Rieko, Suda Koichi, Hayashida Testu, Wada Norihito, Kitagawa Yuko
Abstract excerpt
BACKGROUND: Although chemotherapy is a core treatment for esophageal cancer, some patients develop drug resistance. Gene screening with transposons (i.e. mobile genetic elements) is a novel procedure for identifying chemotherapy-resistant genes. Transposon insertion can randomly affect nearby gene expression. By identifying the affected genes, candidate genes can be found. The present study aimed to identify...
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