Article
Dynein mutations impair autophagic clearance of aggregate-prone proteins.
Nature genetics - 1 Jul 2005
Ravikumar Brinda, Acevedo-Arozena Abraham, Imarisio Sara, Berger Zdenek, Vacher Coralie, O'Kane Cahir J, Brown Steve D M, Rubinsztein David C
Abstract excerpt
Mutations that affect the dynein motor machinery are sufficient to cause motor neuron disease. It is not known why there are aggregates or inclusions in affected tissues in mice with such mutations and in most forms of human motor neuron disease. Here we identify a new mechanism of inclusion form...
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