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Article

Systemic Safety of a Recombinant AAV8 Vector for Human Cocaine Hydrolase Gene Therapy: A Good Laboratory Practice Preclinical Study in Mice.

Human gene therapy - 1 Jan 2020

Chen Vicky Ping, Gao Yang, Geng Liyi, Steele Mike, Jenks Nathan, Peng Kah-Whye, Brimijoin Stephen

Abstract excerpt

Cocaine addiction continues to impose major burdens on affected individuals and broader society but is highly resistant to medical treatment or psychotherapy. This study was undertaken with the goal of Food and Drug Administration (FDA) permission for a first-in-human clinical trial of a gene therapy for treatment-seeking cocaine users to become and remain abstinent. The approach was based on intravenous...

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Share to Carboxylic Ester Hydrolases
Share to Cocaine-Related Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug Evaluation, Preclinical

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Source

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Identifiers

PMID: 31650869
DOI: 10.1089/hum.2019.233
PMCID: PMC6985763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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