Article
A two-mutation model of radiation-induced acute myeloid leukemia using historical mouse data.
Radiation and environmental biophysics - 1 Mar 2011
Dekkers Fieke, Bijwaard Harmen, Bouffler Simon, Ellender Michele, Huiskamp René, Kowalczuk Christine, Meijne Emmy, Sutmuller Marjolein
Abstract excerpt
From studies of the atomic bomb survivors, it is well known that ionizing radiation causes several forms of leukemia. However, since the specific mechanism behind this process remains largely unknown, it is difficult to extrapolate carcinogenic effects at acute high-dose exposures to risk estimates for the chronic low-dose exposures that are important for radiation protection purposes. Recently, it has become...
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