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Article

Application of CRISPR-Cas9 gene editing for congenital heart disease

2 Mar 2021

Abstract excerpt

Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9 (CRISPR-Cas9) is an ancient prokaryotic defense system that precisely cuts foreign genomic DNA under the control of a small number of guide RNAs. The CRISPR-Cas9 system facilitates efficient double-stranded DNA cleavage that has been recently adopted for genome editing to create or correct inherited genetic mutations causing...

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PMID: 33677855
DOI: 10.3345/cep.2020.02096

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