Article
Histone H3K36I mutation in a metastatic histiocytic tumor of the skull and response to sarcoma chemotherapy.
Cold Spring Harbor molecular case studies - 1 Oct 2019
Snuderl Matija, Dolgalev Igor, Heguy Adriana, Walsh Michael F, Benayed Ryma, Jungbluth Achim A, Ladanyi Marc, Karajannis Matthias A
Abstract excerpt
Recurrent somatic missense mutations in histone H3 genes have been identified in subsets of pediatric cancers. H3K36 histone mutations have recently been recognized as oncogenic drivers in rare subsets of malignant soft tissue sarcomas but have not been reported in histiocytic neoplasms. Currently, the histological and molecular spectrum, as well as the clinical behavior of H3K36-mutant soft tissue malignancies,...
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