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Article

Clinical significance of filamin A in patients with acromegaly and its association with somatostatin and dopamine receptor profiles

4 Feb 2019

Abstract excerpt

Filamin-A (FLNA) plays a crucial role in somatostatin receptor (sst) subtype-2 signaling in somatotropinomas. Our objective was to investigate the in vivo association between FLNA and sst2 expression, sst5 expression, dopamine receptor subtype-2 (D2) expression, somatostatin receptor ligand (SRL) responsiveness and tumor invasiveness in somatotropinomas. Quantitative real-time PCR was used to evaluate the...

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PMID: 30718563
DOI: 10.1038/s41598-018-37692-3

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