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Article

Genome-wide association studies using binned genotypes.

Heredity - 1 Feb 2020

An Bingxing, Gao Xue, Chang Tianpeng, Xia Jiangwei, Wang Xiaoqiao, Miao Jian, Xu Lingyang, Zhang Lupei, Chen Yan, Li Junya, Xu Shizhong, Gao Huijiang

Abstract excerpt

Linear mixed models (LMM) that tests trait association one marker at a time have been the most popular methods for genome-wide association studies. However, this approach has potential pitfalls: over conservativeness after Bonferroni correction, ignorance of linkage disequilibrium (LD) between neighboring markers, and power reduction due to overfitting SNP effects. So, multiple locus models that can...

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PMID: 31641238
DOI: 10.1038/s41437-019-0279-y
PMCID: PMC6972794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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