Signatures of natural selection in the drug metabolizing enzyme genes: Opportunity for developing personalized and precision medicine

Abstract excerpt

Modern human experienced various selective pressures; including range of xenobiotics which contributed to heterogeneity of drug response. Many genes involve in pharmacokinetics and dynamics of drug, have been reported under natural selection. However, none of the studies have utilized comprehensive information of drug-centered PharmGKB pathways. We have extended this work and aimed to investigate sweep signals, us...

Topics

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• Cytochromes b
• Drug Design
• Drug Therapy
• Genome, Human
• Models, Molecular
• Pharmacogenetics
• Polymorphism, Single Nucleotide
• Protein Conformation

Identifiers and source

Literature Corpus work

6f334c90-3849-54c7-8b15-b257c29a8627

DOI

10.1101/113514