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Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia

14 Oct 2019

Abstract excerpt

Abstract Inappropriate localization of proteins can interfere with normal cellular function and drive tumor development. To understand how this contributes to the development of acute myeloid leukemia (AML), we compared the nuclear proteome and transcriptome of AML blasts with normal human CD34 + cells. Analysis of the proteome identified networks and processes that significantly affected transcription regulation...

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PMID: 31611628
DOI: 10.1038/s41375-019-0596-4

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