Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Downregulation of microRNA-100 protects apoptosis and promotes neuronal growth in retinal ganglion cells

17 Nov 2014

Abstract excerpt

BACKGROUND: Retinal ganglion cells (RGCs) are preferentially lost in glaucoma or optic neuritis. In the present study, we investigated the protective effect of mircoRNA 100 (miR-100) against oxidative stress induced apoptosis in RGC-5 cells. RESULTS: Rat RGC-5 cells were cultured in plates and H2O2 was added to induce oxidative stress. TUNEL assay and qRT-PCR showed H2O2 induced apoptosis and up-regulated miR-100...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glaucoma and retinal disorders
Share to MicroRNA in disease regulation
Share to Retinal Development and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25406880
DOI: 10.1186/s12867-014-0025-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Downregulation of microRNA-100 protects apoptosis and promotes neuronal growth in retinal ganglion cellsPMID 25406880Read ↗

Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injurySemantic proximity Read ↗

Retinal Ganglion Cell Death in Glaucoma: Advances and CaveatsSemantic proximity Read ↗

Silencing of GAS5 Alleviates Glaucoma in Rat Models by Reducing Retinal Ganglion Cell ApoptosisSemantic proximity Read ↗

Melatonin As a Modulator of Degenerative and Regenerative Signaling Pathways in Injured Retinal Ganglion CellsSemantic proximity Read ↗

Neuroprotective Effects of Propylgallate Against Oxidative Stress in Retinal Ganglion CellsSemantic proximity Read ↗

miR-708 and miR-335-3p Inhibit the Apoptosis of Retinal Ganglion Cells Through Suppressing AutophagySemantic proximity Read ↗

The molecular mechanisms underlying retinal ganglion cell apoptosis and optic nerve regeneration in glaucoma (Review)Semantic proximity Read ↗

Dysregulation of the circRNA_0087207/miR-548c-3p/PLSR1-TGFB2 axis in Leber hereditary optic neuropathy in vitro.Semantic proximity Read ↗

Glaucoma, apoptosis, and neuroprotectionSemantic proximity Read ↗

MiR-29a-5p engages in the mechanism of diabetic retinopathy by specifically targeting SIRT3Semantic proximity Read ↗

TUNEL-Positive Ganglion Cells in Human Primary Open-angle GlaucomaSemantic proximity Read ↗

Global Gene Expression Changes in Rat Retinal Ganglion Cells in Experimental GlaucomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.