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miR-21 Expression Determines the Early Vaccine Immunity Induced by LdCen−/− Immunization

24 Sept 2019

Abstract excerpt

No vaccine exists against visceral leishmaniasis. Towards developing vaccines against VL, we have reported previously on the immunogenicity of live attenuated LdCen-/- parasites in animal models. Immunization with LdCen-/- parasites has been shown induce durable protective immunity in pre-clinical animal models. Although the innate immune responses favoring a Th1 type immunity are produced following LdCen-/-...

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PMID: 31608064
DOI: 10.3389/fimmu.2019.02273

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