Article
Clinical and functional significance of α9β1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasion.
The Journal of pathology - 1 Apr 2011
Allen Michael D, Vaziri Reza, Green Michael, Chelala Claude, Brentnall Adam R, Dreger Sally, Vallath Sabarinath, Nitch-Smith Harriet, Hayward Jane, Carpenter Robert, Holliday Deborah L, Walker Rosemary A, Hart Ian R, Jones J Louise
Abstract excerpt
Integrin α9β1 is a receptor for ECM proteins, including Tenascin-C and the EDA domain of fibronectin, and has been shown to transduce TGFβ signalling. This study has examined the expression pattern of α9β1 in 141 frozen breast carcinoma samples and related expression to prognostic indices, molecular subtype and patient outcome. Effects of α9β1 on tumour cell migration and invasion were assessed using blocking...
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