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Article

The prognostic significance of wild-type isocitrate dehydrogenase 2 (IDH2) in breast cancer

10 Oct 2019

Abstract excerpt

BACKGROUND: Lymphovascular invasion (LVI) is a prerequisite step in breast cancer (BC) metastasis. We have previously identified wild-type isocitrate dehydrogenase 2 (IDH2) as a key putative driver of LVI. Thus, we explored the prognostic significance of IDH2 at transcriptome and protein expression levels in pre-invasive and invasive disease. METHODS: Utlising tissue microarrays from a large well annotated BC...

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PMID: 31599393
DOI: 10.1007/s10549-019-05459-7

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