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Insights from pharmacokinetic models of host-microbiome drug metabolism

29 Sept 2019

Abstract excerpt

Increasing evidence suggests a role of the gut microbiota in patients' response to medicinal drugs. In our recent study, we combined genomics of human gut commensals and gnotobiotic animal experiments to quantify microbiota and host contributions to drug metabolism. Informed by experimental data, we built a physiology-based pharmacokinetic model of drug metabolism that includes intestinal compartments with...

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PMID: 31564204
DOI: 10.1080/19490976.2019.1667724

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