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Article

CTC-Derived Models: A Window into the Seeding Capacity of Circulating Tumor Cells (CTCs)

25 Sept 2019

Abstract excerpt

Metastasis is the main cause of cancer-related death owing to the blood-borne dissemination of circulating tumor cells (CTCs) early in the process. A rare fraction of CTCs harboring a stem cell profile and tumor initiation capacities is thought to possess the clonogenic potential to seed new lesions. The highest plasticity has been generally attributed to CTCs with a partial epithelial-to-mesenchymal transition...

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PMID: 31557946
DOI: 10.3390/cells8101145

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