In Vitro Model-Systems to Understand the Biology and Clinical Significance of Circulating Tumor Cell Clusters

Abstract excerpt

The isolation of clusters of circulating tumor cells (CTCs) from cancer patients has recently challenged the accepted view that the initiation of secondary tumors during metastasis involves the dissemination of individual cancer cells. As such clusters appear to be more aggressive than single tumor cells, CTC clusters are now considered a main player in the metastatic process, and many studies are exploring their...

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