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Gene mutations associated with early onset familial Alzheimer's disease in China: An overview and current status.

Molecular genetics & genomic medicine - 1 Oct 2020

Qin Qi, Yin Yunsi, Wang Yan, Lu Yuanyuan, Tang Yi, Jia Jianping

Abstract excerpt

BACKGROUND: Mutations of three causative genes, namely presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein (APP), have been identified as the major causes of early-onset familial Alzheimer's disease (EOFAD). The prevalence of causative gene mutations in patients with EOFAD has been reported in previous studies worldwide but remains unclear in China. The patients with these known mutations...

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PMID: 32767553
DOI: 10.1002/mgg3.1443
PMCID: PMC7549583

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Source receipt: pubmed, retrieved 7 Sept 2026.

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