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Article

Dissecting the Role of DDX21 in Regulating Human Cytomegalovirus Replication

25 Sept 2019

Abstract excerpt

Previous studies have confirmed that DDX21 is vital for the regulation of various aspects of RNA virus replication. Our research is the first report on the role of DDX21 in HCMV DNA virus replication. We identified that DDX21 knockdown affected HCMV growth and viral late gene transcription. In order to elucidate how DDX21 regulated this transcription, we applied DNA-RNA immunoprecipitation by using the DNA-RNA...

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PMID: 31554690
DOI: 10.1128/jvi.01222-19

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