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Article

MSX2 represses tumor stem cell phenotypes within oral squamous cell carcinomas via SOX2 degradation.

Experimental biology and medicine (Maywood, N.J.) - 1 Dec 2021

Keyimu Reziwan, Tuerdi Maimaitituxun, Zhao Zhihe

Abstract excerpt

Oral squamous cell carcinoma (OSCC) is the sixth malignancy in the world with high incidence. The MSX2 (muscle segment homeobox 2)-Sry-related high-mobility box 2 (SOX2) signaling pathway plays a significant role in maintaining cancer stem cells, which are the origin of malignancy, leading to unfavorable outcomes in several carcinomas. This study aims to elucidate the mechanisms through which the MSX2-SOX2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34435915
DOI: 10.1177/15353702211041029
PMCID: PMC8669173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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