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Detection of NRAS mutation in cell-free DNA biological fluids from patients with kaposiform lymphangiomatosis

11 Sept 2019

Abstract excerpt

BACKGROUND: Kaposiform lymphangiomatosis (KLA) has recently been distinguished as a novel subtype of generalized lymphatic anomaly (GLA) with foci of spindle endothelial cells. All cases of KLA involve multiple organs and have an unfavorable prognosis. However, the molecular pathogenesis is unknown, and there are no useful biomarkers. In the present study, we performed genetic analysis to elucidate the cause of...

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PMID: 31511039
DOI: 10.1186/s13023-019-1191-5

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