Cofilin, an intracellular marker for HIV‐associated CD4 T‐cell motility dysregulation, shed light on the mechanisms of incomplete immune reconstitution in the patients with HIV

Abstract excerpt

Highlights People living with HIV do not achieve an optional immune reconstitution despite the sustained virologic suppression. Circulating CD4 T cells fail to replenish their lymphoid tissue counterparts in people living with HIV. Irrespective of ART, coffin hyperactivation and impaired T cell mobility persist in people living with HIV. Cofilin may represent a novel therapeutic target to restore T cell mobility...

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