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Article

Cellular effector mechanisms against<i>Plasmodium</i>liver stages

18 Jul 2008

Abstract excerpt

Advances in our understanding of the molecular and cell biology of the malaria parasite have led to new vaccine development efforts resulting in a pipeline of over 40 candidates undergoing clinical phase I-III trials. Vaccine-induced CD4+ and CD8+ T cells specific for pre-erythrocytic stage antigens have been found to express cytolytic and multi-cytokine effector functions that support a key role for these T...

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PMID: 18647171
DOI: 10.1111/j.1462-5822.2008.01211.x

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