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Article

ASO silencing of a glycosyltransferase, Poglut1 , improves the liver phenotypes in mouse models of Alagille syndrome.

Hepatology (Baltimore, Md.) - 1 Nov 2023

Niknejad Nima, Fox Duncan, Burwinkel Jennifer L, Zarrin-Khameh Neda, Cho Soomin, Soriano Armand, Cast Ashley E, Lopez Mario F, Huppert Kari A, Rigo Frank, Huppert Stacey S, Jafar-Nejad Paymaan, Jafar-Nejad Hamed

Abstract excerpt

BACKGROUND AND AIMS: Paucity of intrahepatic bile ducts (BDs) is caused by various etiologies and often leads to cholestatic liver disease. For example, in patients with Alagille syndrome (ALGS), which is a genetic disease primarily caused by mutations in jagged 1 ( JAG1) , BD paucity often results in severe cholestasis and liver damage. However, no mechanism-based therapy exists to restore the biliary system in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Glucosyltransferases

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Share to Oligonucleotides, Antisense

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Identifiers

PMID: 37021797
DOI: 10.1097/HEP.0000000000000380
PMCID: PMC10558624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ASO silencing of a glycosyltransferase, Poglut1 , improves the liver phenotypes in mouse models of Alagille syndrome.PMID 37021797Read ↗

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