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Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design

18 Nov 2016

Abstract excerpt

Recent outbreak of flavivirus Zika virus (ZIKV) in America has urged the basic as well as translational studies of this important human pathogen. The nonstructural protein 5 (NS5) of the flavivirus has an N-terminal methyltransferase (MTase) domain that plays critical roles in viral RNA genome capping. The null mutant of NS5 MTase is lethal for virus. Therefore, NS5 is a potential drug target for the treatment of...

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PMID: 27866982
DOI: 10.1016/j.bbrc.2016.11.098

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