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Neocarzilin A Is a Potent Inhibitor of Cancer Cell Motility Targeting VAT-1 Controlled Pathways

18 Jun 2019

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide The natural product neocarzilin A ( NCA ) was discovered decades ago, and despite its potent cytotoxic effects no mode of action studies have been performed up to date. Synthesis of neocarzilins A, B, and C and a stereoisomer of NCA provided insights into structural preferences as well as access to probes for functional studies. NCA turned out to be the most...

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PMID: 31403069
DOI: 10.1021/acscentsci.9b00266

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