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Article

Targeting the MMP-14/MMP-2/integrin αvβ3 axis with multispecific N-TIMP2-based antagonists for cancer therapy.

The Journal of biological chemistry - 24 Aug 2018

Yosef Gal, Arkadash Valeria, Papo Niv

Abstract excerpt

The pathophysiological functions of the signaling molecules matrix metalloproteinase-14 (MMP-14) and integrin αvβ3 in various types of cancer are believed to derive from their collaborative activity in promoting invasion, metastasis, and angiogenesis, as shown in vitro and in vivo The two effectors act in concert in a cell-specific manner through the localization of pro-MMP-2 to the cell surface, where it is...

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Source

Open in PubMed Open full text

Identifiers

PMID: 29986882
DOI: 10.1074/jbc.RA118.004406
PMCID: PMC6109916

Genes

TIMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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