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Article

Identifying potential novel drugs against Helicobacter pylori by targeting the essential response regulator HsrA

5 Aug 2019

Abstract excerpt

The increasing antibiotic resistance evolved by Helicobacter pylori has alarmingly reduced the eradication rates of first-line therapies. To overcome the current circulating resistome, we selected a novel potential therapeutic target in order to identify new candidate drugs for treating H. pylori infection. We screened 1120 FDA-approved drugs for molecules that bind to the essential response regulator HsrA and...

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PMID: 31383920
DOI: 10.1038/s41598-019-47746-9

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