Hypermethylation of Sp1 Binding Site Suppresses Hypothalamic <i>POMC</i> in Neonates and May Contribute to Metabolic Disorders in Adults: Impact of Maternal Dietary CLAs

Abstract excerpt

Epigenetic regulation of neuropeptide genes associated with central appetite control plays an important part in the development of nutritional programming. While proopiomelanocortin (POMC) is critical in appetite control, the molecular mechanism of methylation-related regulation of POMC remains unclear. Based on the report that the proximal specificity protein 1 (Sp1) binding site in POMC promoter is crucial for...

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