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Article

Caspase-mediated cleavage of murine norovirus NS1/2 potentiates apoptosis and is required for persistent infection of intestinal epithelial cells

22 Jul 2019

Abstract excerpt

Human norovirus (HNoV) is the leading cause of acute gastroenteritis and is spread by fecal shedding that can often persist for weeks to months after the resolution of symptoms.Elimination of persistent viral reservoirs has the potential to prevent outbreaks.Similar to HNoV, murine norovirus (MNV) is spread by persistent shedding in the feces and provides a tractable model to study molecular mechanisms of enteric...

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PMID: 31329638
DOI: 10.1371/journal.ppat.1007940

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