Article

Coronaviruses exploit a host cysteine-aspartic protease for efficient replication

2021-03-26

Abstract excerpt

<title>Abstract</title> <p>Highly pathogenic coronaviruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)<sup>1,2</sup>, Middle East respiratory syndrome coronavirus (MERS-CoV)<sup>3,4</sup>, and SARS-CoV-1<sup>5</sup> vary in their transmissibility and pathogenicity. However, infection by all three viruses result in substantial apoptosis in cell culture<sup>6-8</sup> and in patient sample...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: df1d4bea-0c20-52ab-8975-f8c7d518856c
DOI: 10.21203/rs.3.rs-354943/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Coronaviruses exploit a host cysteine-aspartic protease for efficient replicationDOI 10.21203/rs.3.rs-354943/v1Read

Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severitySemantic proximity Read

Regulation of cell death during infection by the severe acute respiratory syndrome coronavirus and other coronavirusesSemantic proximity Read

The roles of cellular protease interactions in viral infections and programmed cell death: a lesson learned from the SARS-CoV-2 outbreak and COVID-19 pandemicSemantic proximity Read

A SARS-CoV protein, ORF-6, induces caspase-3 mediated, ER stress and JNK-dependent apoptosisSemantic proximity Read

Apoptosis Induced by the SARS-Associated Coronavirus in Vero Cells Is Replication-Dependent and Involves CaspaseSemantic proximity Read

The role of cell death in SARS-CoV-2 infectionSemantic proximity Read

Apoptosis induced by SARS-CoV-2: can we target it?Semantic proximity Read

SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replicationSemantic proximity Read

Human Immunodeficiency Virus Type 1 Vpr Induces Apoptosis through Caspase ActivationSemantic proximity Read

Caspases: evolutionary aspects of their functions in vertebratesSemantic proximity Read

Caspase-mediated cleavage of murine norovirus NS1/2 potentiates apoptosis and is required for persistent infection of intestinal epithelial cellsSemantic proximity Read

Emerging Insights on Caspases in COVID-19 Pathogenesis, Sequelae, and Directed TherapiesSemantic proximity Read