Article
Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy.
JCI insight - 12 Jan 2017
Kimura Hirotaka, Eguchi Satoshi, Sasaki Junko, Kuba Keiji, Nakanishi Hiroki, Takasuga Shunsuke, Yamazaki Masakazu, Goto Akiteru, Watanabe Hiroyuki, Itoh Hiroshi, Imai Yumiko, Suzuki Akira, Mizushima Noboru, Sasaki Takehiko
Abstract excerpt
Hypertrophic cardiomyopathy (HCM) is a common heart disease with a prevalence of 1 in 500 in the general population. Several mutations in genes encoding cardiac proteins have been found in HCM patients, but these changes do not predict occurrence or prognosis and the molecular mechanisms underlying HCM remain largely elusive. Here we show that cardiac expression of vacuolar protein sorting 34 (Vps34) is reduced...
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