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Article

Notch Inhibition Prevents Differentiation of Human Limbal Stem/Progenitor Cells in vitro

17 Jul 2019

Abstract excerpt

Notch signaling has been shown to regulate the homeostasis and wound healing of the corneal epithelium. We investigated the effect of Notch inhibition in the human limbal stem/progenitor cells (LSCs) in vitro by using small molecules. Treatment of the LSCs with DAPT and SAHM1 reduced the proliferation rate and maintained the undifferentiated state of the LSCs in a concentration dependent manner. Stratification...

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PMID: 31316119
DOI: 10.1038/s41598-019-46793-6

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