Wnt/β-catenin signaling regulates proliferation of human cornea epithelial stem/progenitor cells.

doi:10.1167/iovs.10-6486

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Article

Wnt/β-catenin signaling regulates proliferation of human cornea epithelial stem/progenitor cells.

Investigative ophthalmology & visual science - 1 Jul 2011

Nakatsu Martin N, Ding Zhenhua, Ng Madelena Y, Truong Thuy T, Yu Fei, Deng Sophie X

Abstract excerpt

PURPOSE: To investigate the expression and role of the Wnt signaling pathway in human limbal stem cells (LSCs). METHODS: Total RNA was isolated from the human limbus and central cornea. Limbal or cornea-specific transcripts were identified through quantitative real-time PCR. Protein expression of Wnt molecules was confirmed by immunohistochemistry on human ocular tissue. Activation of Wnt signaling using lithium...

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Identifiers

PMID: 21357396
DOI: 10.1167/iovs.10-6486
PMCID: PMC3175950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.