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Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro

14 Jan 2019

Abstract excerpt

Purpose: A chemical approach to examine the role of Wnt signaling in maintaining the stemness and/or proliferation of limbal stem/progenitor cells (LSCs). Methods: LSCs were isolated from human donor eyes and cultured as single cells for 12 to 14 days with the following small molecules: IIIC3, an antagonist of the Wnt signaling inhibitor Dickkopf (DKK), and IC15, a Wnt signaling inhibitor. Proliferation of LSCs...

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PMID: 30640975
DOI: 10.1167/iovs.18-25740

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