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Article

High-Throughput Yeast Aging Analysis for Cryptococcus (HYAAC) microfluidic device streamlines aging studies in Cryptococcus neoformans.

Communications biology - 1 Jan 2019

Orner Erika P, Zhang Pengchao, Jo Myeong C, Bhattacharya Somanon, Qin Lidong, Fries Bettina C

Abstract excerpt

Cryptococcus neoformans (Cn) is a deadly fungal pathogen responsible for ~ 180,000 deaths per year and despite effective antifungals, treatment failure and resistance to antifungals are increasingly problematic. Aging and age-related phenotypes are prominent virulence traits that contribute to the resilience of Cn to host responses and antifungals. Traditional methods to study aging in Cn are expensive,...

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Identifiers

PMID: 31312725
DOI: 10.1038/s42003-019-0504-5
PMCID: PMC6620289

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