Article
Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platform.
Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2012
Lee Sung Sik, Avalos Vizcarra Ima, Huberts Daphne H E W, Lee Luke P, Heinemann Matthias
Abstract excerpt
Important insights into aging have been generated with the genetically tractable and short-lived budding yeast. However, it is still impossible today to continuously track cells by high-resolution microscopic imaging (e.g., fluorescent imaging) throughout their entire lifespan. Instead, the field still needs to rely on a 50-y-old laborious and time-consuming method to assess the lifespan of yeast cells and to...
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