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Syndecan-4 regulates extravillous trophoblast migration by coordinating protein kinase C activation

15 Jul 2019

Abstract excerpt

Extravillous trophoblast (EVT) invasion is an essential component of human placentation. Poor EVT invasion is associated with obstetrical complications including preeclampsia. Integration of cues from the extracellular environment is required for directional EVT invasion, but how EVTs coordinate responses to these cues is not well understood. Syndecan-4 (SDC4) is a transmembrane heparan sulfate proteoglycan that...

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PMID: 31308409
DOI: 10.1038/s41598-019-46599-6

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