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Article

One in three highly selected Greek patients with breast cancer carries a loss-of-function variant in a cancer susceptibility gene

12 Jul 2019

Abstract excerpt

Background Gene panel testing has become the norm for assessing breast cancer (BC) susceptibility, but actual cancer risks conferred by genes included in panels are not established. Contrarily, deciphering the missing hereditability on BC, through identification of novel candidates, remains a challenge. We aimed to investigate the mutation prevalence and spectra in a highly selected cohort of Greek patients with...

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PMID: 31300551
DOI: 10.1136/jmedgenet-2019-106189

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