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Biosynthetic homeostasis and resilience of the complement system in health and infectious disease

29 Jun 2019

Abstract excerpt

BACKGROUND: The complement system is a central component of the innate immune system. Constitutive biosynthesis of complement proteins is essential for homeostasis. Dysregulation as a consequence of genetic or environmental cues can lead to inflammatory syndromes or increased susceptibility to infection. However, very little is known about steady state levels in children or its kinetics during infection. METHODS:...

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PMID: 31262714
DOI: 10.1016/j.ebiom.2019.06.008

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