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Chemically Defined Media Can Maintain Pig Pluripotency Network In Vitro

27 Jun 2019

Abstract excerpt

Pig embryonic stem cells (pESCs) have been considered an important candidate for preclinical research on human therapies. However, the lack of understanding of pig pluripotent networks has hampered establishment of authentic pESCs. Here, we report that FGF2, ACTVIN, and WNT signaling are essential to sustain pig pluripotency in vitro. Newly derived pESCs were stably maintained over an extended period, and capable...

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PMID: 31257130
DOI: 10.1016/j.stemcr.2019.05.028

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