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ABCB1 protects bat cells from DNA damage induced by genotoxic compounds

27 Jun 2019

Abstract excerpt

Bats are unusual mammals, with the ability to fly, and long lifespans. In addition, bats have a low incidence of cancer, but the mechanisms underlying this phenomenon remain elusive. Here we discovered that bat cells are more resistant than human and mouse cells to DNA damage induced by genotoxic drugs. We found that bat cells accumulate less chemical than human and mouse cells, and efficient drug efflux mediated...

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PMID: 31249297
DOI: 10.1038/s41467-019-10495-4

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