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Notch2 pathway mediates breast cancer cellular dormancy and mobilisation in bone and contributes to haematopoietic stem cell mimicry

25 Jun 2019

Abstract excerpt

Recurrence after >5-year disease-free survival affects one-fifth of breast cancer patients and is the clinical manifestation of cancer cell reactivation after persistent dormancy. We investigated cellular dormancy in vitro and in vivo using breast cancer cell lines and cell and molecular biology techniques. We demonstrated cellular dormancy in breast cancer bone metastasis, associated with haematopoietic stem...

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PMID: 31239543
DOI: 10.1038/s41416-019-0501-y

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