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Article

Revisiting the role of histo-blood group antigens in rotavirus host-cell invasion

5 Jan 2015

Abstract excerpt

Histo-blood group antigens (HBGAs) have been proposed as rotavirus receptors. H type-1 and Lewisb antigens have been reported to bind VP8* from major human rotavirus genotypes P[4], P[6] and P[8], while VP8* from a rarer P[14] rotavirus recognizes A-type HBGAs. However, the role and significance of HBGA receptors in rotavirus pathogenesis remains uncertain. Here we report that P[14] rotavirus HAL1166 and the...

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PMID: 25556995
DOI: 10.1038/ncomms6907

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