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Article

Progress in the identification of gene mutations involved in multiple myeloma

1 May 2019

Abstract excerpt

Abstract: Sequencing studies have been used to determine a spectrum of multiple myeloma (MM) mutations. Mutation of certain genes, including KRAS, NRAS, TP53, FAM46C, DIS3 and BRAF , have a high recurrence rate and may play important roles in the pathogenesis, progression and prognosis of MM. Mutations in DIS3 , which encodes a highly conserved RNA exonuclease, lead to loss of function. The expression of FAM46C...

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PMID: 31213829
DOI: 10.2147/ott.s205922

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