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Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway

13 Jun 2019

Abstract excerpt

Bacteria control gene expression in concert with their population density by a process called quorum sensing, which is modulated by bacterial chemical signals and environmental factors. In the human pathogen Streptococcus pyogenes, production of secreted virulence factor SpeB is controlled by a quorum-sensing pathway and environmental pH. The quorum-sensing pathway consists of a secreted leaderless peptide signal...

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PMID: 31197146
DOI: 10.1038/s41467-019-10556-8

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