Article
The leaderless communication peptide (LCP) class of quorum-sensing peptides is broadly distributed among Firmicutes.
Nature communications - 23 Sept 2023
Aggarwal Shifu, Huang Elaine, Do Hackwon, Makthal Nishanth, Li Yanyan, Bapteste Eric, Lopez Philippe, Bernard Charles, Kumaraswami Muthiah
Abstract excerpt
The human pathogen Streptococcus pyogenes secretes a short peptide (leaderless communication peptide, LCP) that mediates intercellular communication and controls bacterial virulence through interaction with its receptor, RopB. Here, we show that LCP and RopB homologues are present in other Firmicutes. We experimentally validate that LCPs with distinct peptide communication codes act as bacterial intercellular...
Topics
- Humans
- Bacillota
- Quorum Sensing
- Cell Communication
- Peptides
- Phenotype