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Article

Sex-dependent effects of MC4R genotype on HPA axis tone: implications for stress-associated cardiometabolic disease

11 Jun 2019

Abstract excerpt

The melanocortin-4 receptor (MC4R) facilitates hypothalamic–pituitary–adrenocortical (HPA) axis responses to acute stress in male rodents and is a well known to regulator of energy balance. Mutations in the MC4R is the most common monogenic cause of obesity in humans and has been associated with sex-specific effects, but whether stress regulation by the MC4R is sex-dependent, and whether the MC4R facilitates HPA...

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PMID: 31184537
DOI: 10.1080/10253890.2019.1610742

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