Article
Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo.
The Journal of biological chemistry - 26 Jul 2019
Lomash Richa Madan, Petralia Ronald S, Holtzclaw Lynne A, Tsuda Mumeko C, Wang Ya-Xian, Badger John D, Cameron Heather A, Youle Richard J, Roche Katherine W
Abstract excerpt
Neurolastin is a dynamin family GTPase that also contains a RING domain and exhibits both GTPase and E3 ligase activities. It is specifically expressed in the brain and is important for synaptic transmission, as neurolastin knockout animals have fewer dendritic spines and exhibit a reduction in functional synapses. Our initial study of neurolastin revealed that it is membrane-associated and partially co-localizes...
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